We undertook this study to determine the relationship among -174G>C and 598G>A polymorphisms in the promoter region of interleukin-6, obesity, and metabolic abnormalities in subjects from central Mexico.
Included in the study were 150 subjects who were not first-degree relatives of patients with diabetes and 106 blood samples from the general population. All were genotyped using polymerase chain reaction (PCR) restriction fragment-length polymorphism. Logistic regression analysis was used to assess the relationships among haplotypes, obesity, and metabolic abnormalities.
Only 2 haplotypes were observed: the -174G -598G and -174C -598A (D′=1.00). The -174G -598G-haplotype was associated with type 2 diabetes (OR 3.35, 95%, CI 1.16–9.71). The relationship of obesity with insulin insensitivity and obesity with hyperinsulinemia was modified by the presence of this haplotype (from OR 10.07, 95% CI 3.86–23.30 to OR 12.20, 95% CI 4.40–33.85 and OR 6.70, 95% CI 2.02–22.23 to OR 8.08, 95% CI 2.28–28.62, respectively).
In the Mexican population, interleukin-6 haplotypes are associated with diabetes, suggesting that their contribution may be by means of modifying the relationship between obesity and metabolic abnormalities.
Irma Zamora-Ginez, MSc, Maria del Carmen Sánchez-Guillén, PhD, Ricardo Pérez-Fuentes, MD, PhD, Blanca G. Baez-Duarte, MSc, Eduardo Brambila, PhD, Alejandra García-Zapién, PhD, Francisco Mendoza-Carrera, PhD Multidisciplinary Research Group on Diabetes
Laboratory Medicine, Volume 41, Issue 10, October 2010, Pages 597–600, https://doi.org/10.1309/LMYAPH6D6VOFA3RF
01 October 2010